I have interviewed Dr. Richard Doyle, PhD, founder of the Penn State Center for Altered Consciousness, teaches classes on William S. Burroughs and Philip K. Dick, and author of the new book Darwin’s Pharmacy: Sex, Plants, and the Evolution of the Noosphere. There will also be my interview Mitch Altman, CEO of Cornfield Electronics, and inventor of the Brain Machine and Trip Glasses.
Dr. Richard Doyle’s websites:
Abstract: Occurrence of a Novel Cannabimimetic Molecule 2-Sciadonoylglycerol (2-Eicosa-5′, 11′, 14′-trienoylglycerol) in the Umbrella Pine Sciadopitys verticillata Seeds
Biological & pharmaceutical bulletin 23(6), 758-761, 2000-06-01
Nakane S, Tanaka T, Satouchi K, Kobayashi Y, Waku K, Sugiura T.
The umbrella pine Sciadopitys verticillata seeds were found to contain a substantial amount (16.7 nmol/g) of sciadonic acid (all-cis-5,11,14-eicosatrienoic acid)-containing 2-monoacylglycerol, i.e., 2-sciadonoylglycerol (2-eicosa-5′, 11′, 14′-trienoylglycerol). Because the structure of 2-sciadonoylglycerol closely resembles that of 2-arachidonoylglycerol, the endogenous natural ligand for the cannabinoid receptor, we examined whether or not 2-sciadonoylglycerol exhibits cannabimimetic activity using NG108-15 neuroblastoma×glioma hybrid cells which express the cannabinoid CB1 receptor. We found that 2-sciadonoylglycerole induces rapid transient elevation of intracellular free Ca^ concentration in NG108-15 cells through a cannabinoid CB1 receptor-dependent mechanism similar to the case of 2-arachidonoylglycerol, yet the activity of 2-sciadonoylglycerol was apparently lower than that of 2-arachidonoylglycerol. The activity of 2-sciadonoylglycerol was detectable from 3-10 nM, reaching a maximum at around 10 μM. To our knowledge, this is the first report showing the occurrence of a cannabimimetic monoacylglycerol in higher plants.
Nature has an interesting article on tDCS (transcranial Direct-Current Stimulation). Check it out: http://www.nature.com/news/2011/110413/full/472156a.html
Thanks to everyone who came to the talk! Remember, we are still seeking submissions. Video of the talk will be available eventually and will be posted here. You can check out the slides from the talk here: https://docs.google.com/present/edit?id=0ATEpiCXs9x31ZGc2OTQyZHNfMjBnazhuZDZkZA&hl=en
Transcranial Pulsed Ultrasound (aka Ultrasonic Neuromodulation) is a new brain stimulation technology which we will be covering a lot in the future. DARPA and Arizona State University researchers are developing the new technology for military and medical applications. Like rTMS (Transcranial Magnetic Stimualtion) its non-invasive, but unlike rTMS it has a much higher spatial resolution, allowing it to stimulate deep inside the brain. It would be great if an open source Transcranial Pulsed Ultrasound project got started.
Check out this article from Armed With Science: Remote Control of Brain Activity Using Ultrasound
And check out this abstract:
Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits
(Click Here for full PDF)
Tufail, Yusuf; Matyushov, Alexei; Baldwin, Nathan; Tauchmann, Monica L.; Georges, Joseph; Yoshihiro, Anna; Tillery, Stephen I. Helms; Tyler, William J. Neuron doi:10.1016/j.neuron.2010.05.008 (volume 66 issue 5 pp.681 – 694)
Electromagnetic-based methods of stimulating brain activity require invasive procedures or have other limitations. Deep-brain stimulation requires surgically implanted electrodes. Transcranial magnetic stimulation does not require surgery, but suffers from low spatial resolution. Optogenetic-based approaches have unrivaled spatial precision, but require genetic manipulation. In search of a potential solution to these limitations, we began investigating the influence of transcranial pulsed ultrasound on neuronal activity in the intact mouse brain. In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01�C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.
Piper methysticum, or kava, also known as, kava kava, ‘awa, ‘ava, yaqona, and sakau, has been used since ancient times by many cultures of the Pacific islands. In many areas kava is traditionally consumed as a drink. Prepared by grinding kava roots and adding a little bit of cold water, this emulsion is placed in the mouth and chewed. Other traditional forms of use are prepared by grinding the root and steeping it in cold water and then drinking it. The primary active constituents of kava are kavalactones, a group of 18 lactones found mainly in the roots of Piper methysticum, a member of the pepper femily. Its popularity as an herbal supplement is well known and during the 90s it was commonly found anywhere herbal remedies were sold. In the past decade kava has become less common on store shelves. This came after the FDA claimed kava could cause liver damage. It is thought claims of liver damage may have come from those using inferior kava products made in Europe and elsewhere, that included the cheap aerial parts of the kava plant. Traditionally only the belowground parts, the root and rhizome, are used. Liver damage is not associated with traditional kava use in the Pacific. There is no good causal evidence to suggest kava root and kavalactone use cause liver damage. To make matters worse, the DEA placed kava under its drugs of concern.
There is nothing inherent in kava or kavalactone use that causes health or criminal problems. But don’t be surprised if the media or the DEA/FDA/DHHS drum up some propaganda scare stories, that is of course their style. This would financially devastate many people who make a living growing or distributing kava. Lets not forget that kava has been used traditionally in Hawaii and American Samoa. Recently, kava bars have sprung up throughout the mainland US. Kava can be a great alternative to alcohol for a relaxing drink at the end of the day. Its also finding its way into “anti-energy” or relaxation drinks.
I have tried kava in the past and enjoyed it, it is good for anxiety, similar to the benzodiazepines. It is theorized that the kavalactones found in kava mainly produce effects through potentiating GABA-A activity. One interesting thing is that unlike benzodiazepines, research has shown kava extract to ENHANCE cognitive function.
PART 2 COMING
Check out this research:
Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). Full PDF Here
Thompson R, Ruch W, Hasenöhrl RU.
Department of Psychology, University of Hertfordshire, College Lane, Hatfield, Herts AL10 9AB, UK.
The acute effects of the herbal anxiolytic Kava-kava (Piper methysticum G. Forster) on emotional reactivity and cognitive performance were investigated in a double-blind randomized placebo-controlled trial involving healthy volunteers. Subjects’ reports of mood change were assessed with the state-trait-cheerfulness-inventory, which measures the three concepts of cheerfulness, seriousness and bad mood as both traits and states. Cognitive performance was examined with the Sperling partial report and the Sternberg item recognition task, which were used as an index for visual attention and short-term memory processing. The intake of a single dose of Kava extract (300 mg; p.o.) led to an increase in state cheerfulness, while the phytopharmacon did not influence state seriousness and bad mood. The mood-elevating effects of Kava were most prominent in trait cheerful subjects, indicating that trait cheerfulness moderated the drug-induced increase in cheerful mood. Furthermore, Kava improved the accuracy and the speed of performing the partial report and the item recognition task, indicative of a beneficial effect of the phytopharmacon on visual attention and short-term memory retrieval, respectively. Thus, unlike conventional benzodiazepine-type anxiolytics, which tend to impair cognitive performance and to increase the occurrence of negative affective states, Kava is a potent anxiolytic agent, which, additionally, can facilitate cognitive functioning and can increase positive affectivity related to exhilaration.