Monthly Archives: April 2011
Abstract: Occurrence of a Novel Cannabimimetic Molecule 2-Sciadonoylglycerol (2-Eicosa-5′, 11′, 14′-trienoylglycerol) in the Umbrella Pine Sciadopitys verticillata Seeds
Biological & pharmaceutical bulletin 23(6), 758-761, 2000-06-01
Nakane S, Tanaka T, Satouchi K, Kobayashi Y, Waku K, Sugiura T.
The umbrella pine Sciadopitys verticillata seeds were found to contain a substantial amount (16.7 nmol/g) of sciadonic acid (all-cis-5,11,14-eicosatrienoic acid)-containing 2-monoacylglycerol, i.e., 2-sciadonoylglycerol (2-eicosa-5′, 11′, 14′-trienoylglycerol). Because the structure of 2-sciadonoylglycerol closely resembles that of 2-arachidonoylglycerol, the endogenous natural ligand for the cannabinoid receptor, we examined whether or not 2-sciadonoylglycerol exhibits cannabimimetic activity using NG108-15 neuroblastoma×glioma hybrid cells which express the cannabinoid CB1 receptor. We found that 2-sciadonoylglycerole induces rapid transient elevation of intracellular free Ca^ concentration in NG108-15 cells through a cannabinoid CB1 receptor-dependent mechanism similar to the case of 2-arachidonoylglycerol, yet the activity of 2-sciadonoylglycerol was apparently lower than that of 2-arachidonoylglycerol. The activity of 2-sciadonoylglycerol was detectable from 3-10 nM, reaching a maximum at around 10 μM. To our knowledge, this is the first report showing the occurrence of a cannabimimetic monoacylglycerol in higher plants.
Nature has an interesting article on tDCS (transcranial Direct-Current Stimulation). Check it out: http://www.nature.com/news/2011/110413/full/472156a.html
Thanks to everyone who came to the talk! Remember, we are still seeking submissions. Video of the talk will be available eventually and will be posted here. You can check out the slides from the talk here: https://docs.google.com/present/edit?id=0ATEpiCXs9x31ZGc2OTQyZHNfMjBnazhuZDZkZA&hl=en